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MEET THE TEAM

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   Associate Professor Marian Burr

Team Leader

A/Prof Marian Burr is a clinician scientist and head of the Cancer Immunology and Epigenetics Laboratory. Marian completed medical school and early clinical training in the UK, before undertaking a PhD in immunology at the University of Cambridge working with Prof Paul Lehner. She subsequently pursued specialist clinical training in anatomical pathology and established a cancer immunology research program in Cambridge. She moved to Melbourne in 2016 supported by a Cancer Research UK Clinician Scientist Fellowship, where she trained in cancer epigenetics with Prof Mark Dawson at the Peter MacCallum Cancer Centre. In 2021, she established a research lab at ANU as a Snow Fellow and NHMRC Investigator. Her research encompasses cancer cell biology, epigenetics and immune regulation and is coupled with a clinical interest in the pathology of lung cancer and other thoracic malignancies. Employing genome scale functional genetic screening her program has uncovered new targets for cancer immunotherapy, published in high-impact journals such as Nature, Cancer Cell and Nature Cell Biology, and ultimately aims to develop new, more effective immune based cancer treatments. https://snowmedical.org.au/fellow/doctor-marian-burr/
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Sarah Popp

     Lab Manager

Background : Sarah studied BSc at ANU before joining the Transplantation/Immunobiology Laboratory at JCSMR with A.Prof Charmaine Simeonovic in 1999. Research - She joined the Burr Laboratory in August 2021 and alongside Juliana, helped A.Prof Marian Burr establish her new laboratory. Sarah spends her days doing a little bit of everything to help support the growing lab operate effectively and efficiently.
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Dr. Chelisa Cardinez

      Postdoctoral Fellow

Background: Chelisa received her PhD in 2022 at the Australian National University where she studied the role of IKK2 protein in regulatory T cell function and immune diseases such as immunodeficiency and psoriasis. Research: She joined the Burr lab in March 2022 where she is currently investigating immune evasion mechanisms in cancers such as melanoma and lung cancer.
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Dr. Rachel Woodhouse

Postdoctoral Fellow

Background: Rachel completed her PhD at the University of Sydney where she characterized mechanisms of epigenetic inheritance. Research: She joined the Burr Group as a postdoc in 2022 and is investigating epigenetic dependencies in EZH2-mutant lymphoma. She is fascinated by unravelling epigenetic mechanisms and exploring their manipulation as novel cancer therapies.

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Dr. Francesco Casciello

Postdoctoral Fellow

Background: Francesco earned his PhD in 2020 from Queensland University of Technology (QUT), where his research focused on the role epigenetic enzymes play in cancer cell adaptation to changes in the tumor microenvironment. He explored the potential of targeting these proteins as innovative therapeutic strategies for aggressive subtypes of breast and ovarian cancer types. Research: In 2024, Francesco joined Burr Lab, where he is investigating the epigenetic mechanisms able to modulate immune responses in cancer. E: francesco.casciello@anu.edu.au
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Xianghan Li

        BioInformatician 

Xianghan completed her Master’s degree in 2019 at the Research School of Biology, Australian National University, where she conducted a bioinformatics project on NSCLC (non-small cell lung cancer) evolution under the supervision of Prof. Allen Rodrigo. She subsequently worked as a Bioinformatician in China from 2020 to 2023, focusing on precision medicine for cancer at Beijing ImmuPeutics Medicine before moving to the BGI Group (Shenzhen). In October 2023, Xianghan joined the Burr Lab as a Bioinformatician, specialising in the analysis of mechanisms of immune escape in cancer.
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Binu Bakhati

        Administration Officer

Background: Binu completed her bachelor's in Microbiology from Trichandra University in Nepal and moved to Australia and completed her master's from Charles Sturt University in 2019. Research: Binu joined Burr Lab in May 2024 and is currently working as Administration Officer and also assists in lab by doing little bit of everything.

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Juliana Gomez

       PhD Student

Background: Juliana completed her master’s degree in January 2020 at the University of Melbourne, where she investigated mechanisms of resistance to EGFR inhibitors in glioblastoma. Research: She began working as research officer for A/Prof Marian Burr at Peter MacCallum Cancer Centre in May 2020, investigating epigenetic mechanisms of immune evasion in cancer, and in 2021, moved with the the Burr Lab to the Australian National University. She is currently undertaking a PhD program in cancer immunology and epigenetics in the Burr group.

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Erin Brotherton

     PhD Student

Background: Erin found an interest in science at the University of Adelaide where she graduated with a Bachelor of Science with a major in Immunology. She also completed Honours exploring the control of immune cell migration into solid tumours via chemokine signalling. Research: Erin is now a PhD student in the Burr Laboratory studying the epigenetic regulators of immune evasion in lung cancer, specifically Major Histocompatibility Complexes class I and class II, and how targeting MHC in solid tumours may improve outcomes to immunotherapy.

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Elizabeth Mee

       PhD Student

Background: Lizzy completed her honours project in Adele Lehane's lab at the Research School of Biology at ANU in 2021, where she worked on the characterisation of the PfSulP transporter in Plasmodium falciparum. Research: Lizzy is a PhD student in the Burr Lab and is currently working on a project to develop new treatments for EZH2 mutant Diffuse Large B Cell Lymphoma by understanding the mechanisms of epigenetic dysregulation driving these malignancies. She previously worked as a Research Assistant in the Burr lab for 12 months. She has experience in CRISPR-Cas9 gene editing and a range of cell and molecular biology techniques - and is excited to keep learning new techniques throughout her PhD!

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Ramin Hosseinzadeh

PhD Student

Background: Ramin completed his Master’s degree in Medical Immunology from Tehran University of Medical Sciences (TUMS), where he conducted research on natural killer (NK) cell exhaustion in patients with endometriosis. Research: He joined the Burr Laboratory as a PhD student to investigate novel immunotherapy targets for lung cancer, utilizing targeted in vivo CRISPR screening to identify potential therapeutic candidates.

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Mahsa Najafzadeh

PhD Student

Background: Mahsa began her academic journey with a Bachelor's degree in Medical Laboratory Science in Iran, where she developed a strong interest in immunology. After completing her Master’s degree in Immunology, she chose to specialise in Cancer Immunology for her PhD. Research: To further strengthen her research background, she worked as a research officer for two years in Iran before commencing her PhD at the Australian National University (ANU). Her doctoral research focuses on gene manipulation using the CRISPR gene screening technique in small cell lung carcinoma (SCLC).

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Callum Duncan-Keen

Research Assistant

Background: Callum completed his Honours degree in the Burr Lab in 2025 where he worked on a project characterising novel epigenetic regulator of small cell lung cancer. In 2026, Callum has started studying a Doctor of Medicine and Surgery (MChD) at the ANU whilst continuing to work on the project. Research: As a Research Assistant, Callum now assists Juliana with understanding the epigenetic mechanisms used by small cell lung cancer and other neuroendocrine carcinomas to develop ‘immune silent’ and aggressive phenotypes. Ultimately, his work aims to help determine how these mechanisms could be manipulated to improve the efficacy of immune-based cancer therapies.

TEAM CATCHUPS

Contact us:  burrlab.jcsmr@anu.edu.au

A/Prof Marian Burr, Building 131, Garran Rd, Acton ACT 2601, Australia,

Acknowledgement of Country
The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

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